What is Rg3?
Rg3 is from Panax ginseng, C.A.Meyer. The most frequent reported uses are: neuroprotection; decrease microglial activation and inflammation, brain trauma
protection, immune enhancement; cancer therapy and general health and protection from conditions sucha as cancer, heart disease, stroke and diabetes.
Rg3, also written Rg(3), is in a class of triterpene saponins called ginsenosides, which are
found in the plant genus Panax (including Asian or Panax ginseng and American ginseng
or Panax quinquifolius). Rg3 is produced by steaming the ginseng root, then extracting
and isolating the Rg3 constituent.
Ginseng root has been traditionally used in Chinese Medicine as a general health tonic.
Today, Panax ginseng is used mainly for its adaptogenic properties. An “adaptogen,” is a
substance that increases nonspecific resistance of the body to a wide range of chemical,
physical, psychological and biological factors (stressors).
Ginsenosides are the major pharmacologically active components of ginseng, and appear
to be responsible for most of the positive effects on the body, including vasorelaxation,
antioxidation, anti-inflammation, hypoglycemic, antifatigue, neuroprotective, immune
modulating and anti-cancer. Approximately 40 ginsenoside compounds have been
identified. Saponin complexes found in ginseng root are often split into two groups: the
Rb group (characterized by the protopanaxadiol presence, including Rb1, Rb2, Rh2, Rc
and Rd) and the Rg group (propanaxatriol, including Rg1, Re, Rf, Rg2 and Rg3).
Purified individual ginsenoside are becoming popular in integrative medicine to treat
various health conditions instead of using whole ginseng root extracts. Individual
ginsenosides may have different effects in pharmacology and mechanisms due to their
different chemical structures.